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Literature summary extracted from

  • Serveau-Avesque, C.; Ferrer-Di Martino, M.; Herve-Grepinet, V.; Hazouard, E.; Gauthier, F.; Diot, E.; Lalmanach, G.
    Active cathepsins B, H, K, L and S in human inflammatory bronchoalveolar lavage fluids (2006), Biol. Cell., 98, 15-22.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.1 [N-(L-3-trans-propylcarbamoyl oxirane-2-carbonyl)-L-isoleucyl-L-proline] specific inhibitor Homo sapiens
3.4.22.16 cystatin C
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.1 Homo sapiens
-
-
-
3.4.22.16 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.1 bronchoalveolar lavage fluid contains the inactive zymogen Homo sapiens
-
3.4.22.1 lung
-
 Homo sapiens
-
3.4.22.16 bronchoalveolar lavage fluid
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.1 benzyloxycarbonyl-L-Arg-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens benzyloxycarbonyl-L-Arg + 7-amino-4-methylcoumarin
-
 ?
3.4.22.1 benzyloxycarbonyl-L-Arg-Arg-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens benzyloxycarbonyl-L-Arg-Arg + 7-amino-4-methylcoumarin
-
 ?
3.4.22.1 benzyloxycarbonyl-L-Phe-Arg-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens benzyloxycarbonyl-L-Phe-Arg + 7-amino-4-methylcoumarin
-
 ?
3.4.22.1 additional information cathepsin B is able to self-activate Homo sapiens ?
-
 ?
3.4.22.1 N-benzyloxycarbonyl-L-Leu-L-Arg 7-amido-4-methylcoumarin + H2O
-
 Homo sapiens benzyloxycarbonyl-L-Leu-L-Arg + 7-amino-4-methylcoumarin
-
 ?
3.4.22.16 L-Arg-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens L-Arg + 7-amino-4-methylcoumarin
-
 ?
3.4.22.16 additional information does not cleave benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin, benzyloxycarbonyl-Leu-Arg-7-amido-4-methylcoumarin, and benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin Homo sapiens ?
-
 ?